Introduction:
Glioblastoma Multiforme (GBM) is one of the most aggressive and common primary brain tumors in adults. Despite medical advancements, it poses a serious challenge due to its rapid growth and resistance to treatment.

Symptoms:

• Persistent headaches

• Nausea or vomiting

• Seizures

• Personality or mood changes

• Memory problems or cognitive decline

Diagnosis:

• MRI with contrast is the gold standard

• Biopsy confirms the type and grade of tumor

• Advanced techniques like MR spectroscopy help assess tumor metabolism

Treatment Options:

• Surgery: Maximal safe resection is the first step

• Radiation therapy: Helps control tumor regrowth

• Chemotherapy: Temozolomide is commonly used

• Experimental options: Immunotherapy and tumor-treating fields (TTF)

Conclusion:
Glioblastoma requires a multidisciplinary approach involving neurosurgeons, oncologists, and rehabilitation teams. While prognosis remains guarded, early detection and comprehensive care can improve quality of life and survival.